Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

Alzheimer disease (AD) is characterized by amyloid-β accumulation, with soluble oligomers (Aβo) being the most synaptotoxic. However, the multivalent and unstable nature of Aβo limits molecular characterization and hinders research reproducibility. Here, we characterized multiple Aβo forms throughou...

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Vydáno v:J Biol Chem
Hlavní autoři: Kostylev, Mikhail A., Kaufman, Adam C., Nygaard, Haakon B., Patel, Pujan, Haas, Laura T., Gunther, Erik C., Vortmeyer, Alexander, Strittmatter, Stephen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498078/
https://ncbi.nlm.nih.gov/pubmed/26018073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.643577
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