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β-amyloid oligomers and cellular prion protein in Alzheimer's disease

Prefibrillar oligomers of the β-amyloid peptide (Aβ) are recognized as potential mediators of Alzheimer's disease (AD) pathophysiology. Deficits in synaptic function, neurotoxicity, and the progression of AD have all been linked to the oligomeric Aβ assemblies rather than to Aβ monomers or to a...

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Detalles Bibliográficos
Main Authors: Gunther, Erik C., Strittmatter, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846635/
https://ncbi.nlm.nih.gov/pubmed/19960174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-009-0568-7
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