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Alzheimer Amyloid-β Oligomer Bound to Post-Synaptic Prion Protein Activates Fyn to Impair Neurons
Amyloid-beta (Aβ) oligomers are thought to trigger Alzheimer’s disease (AD) pathophysiology. Cellular Prion Protein (PrP(C)) selectively binds oligomeric Aβ and can mediate AD-related phenotypes. Here, we examined the specificity, distribution and signaling from Aβ/PrP complexes, seeking to explain...
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主要な著者: | , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2012
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3431439/ https://ncbi.nlm.nih.gov/pubmed/22820466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3178 |
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