Alzheimer Amyloid-β Oligomer Bound to Post-Synaptic Prion Protein Activates Fyn to Impair Neurons

Amyloid-beta (Aβ) oligomers are thought to trigger Alzheimer’s disease (AD) pathophysiology. Cellular Prion Protein (PrP(C)) selectively binds oligomeric Aβ and can mediate AD-related phenotypes. Here, we examined the specificity, distribution and signaling from Aβ/PrP complexes, seeking to explain...

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Detalhes bibliográficos
Main Authors: Um, Ji Won, Nygaard, Haakon B., Heiss, Jacqueline K., Kostylev, Mikhail A., Stagi, Massimiliano, Vortmeyer, Alexander, Wisniewski, Thomas, Gunther, Erik C., Strittmatter, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431439/
https://ncbi.nlm.nih.gov/pubmed/22820466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3178
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