Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

Alzheimer disease (AD) is characterized by amyloid-β accumulation, with soluble oligomers (Aβo) being the most synaptotoxic. However, the multivalent and unstable nature of Aβo limits molecular characterization and hinders research reproducibility. Here, we characterized multiple Aβo forms throughou...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Kostylev, Mikhail A., Kaufman, Adam C., Nygaard, Haakon B., Patel, Pujan, Haas, Laura T., Gunther, Erik C., Vortmeyer, Alexander, Strittmatter, Stephen M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2015
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498078/
https://ncbi.nlm.nih.gov/pubmed/26018073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.643577
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