Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease

Por Haas, Laura T., Salazar, Santiago V., Kostylev, Mikhail A., Um, Ji Won, Kaufman, Adam C., Strittmatter, Stephen M.
Publicado no Brain (2016)

Delayed Amyloid Plaque Deposition and Behavioral Deficits in Outcrossed AβPP/PS1 Mice

Por Couch, Brian A., Kerrisk, Meghan E., Kaufman, Adam C., Nygaard, Haakon B., Strittmatter, Stephen M., Koleske, Anthony J.
Publicado em 2013

Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network

Por Takahashi, Hideyuki, Klein, Zoe A., Sarah, M. Bhagat, Kaufman, Adam C., Kostylev, Mikhail A., Ikezu, Tsuneya, Strittmatter, Stephen M.
Publicado no Acta Neuropathol (2017)

Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

Por Kostylev, Mikhail A., Kaufman, Adam C., Nygaard, Haakon B., Patel, Pujan, Haas, Laura T., Gunther, Erik C., Vortmeyer, Alexander, Strittmatter, Stephen M.
Publicado no J Biol Chem (2015)

Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer’s disease mouse model

Por Nygaard, Haakon B, Kaufman, Adam C, Sekine-Konno, Tomoko, Huh, Linda L, Going, Hilary, Feldman, Samantha J, Kostylev, Mikhail A, Strittmatter, Stephen M
Publicado no Alzheimers Res Ther (2015)

Fyn Inhibition Rescues Established Memory and Synapse Loss in Alzheimer Mice

Por Kaufman, Adam C., Salazar, Santiago V., Haas, Laura T., Yang, Jinhee, Kostylev, Mikhail A., Jeng, Amanda T., Robinson, Sophie A., Gunther, Erik C., van Dyck, Christopher H., Nygaard, Haakon B., Strittmatter, Stephen M.
Publicado no Ann Neurol (2015)

Metabotropic Glutamate Receptor 5 is a Co-Receptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

Por Um, Ji Won, Kaufman, Adam C., Kostylev, Mikhail, Heiss, Jacqueline K., Stagi, Massimiliano, Takahashi, Hideyuki, Kerrisk, Meghan E., Vortmeyer, Alexander, Wisniewski, Thomas, Koleske, Anthony J., Gunther, Erik C., Nygaard, Haakon B., Strittmatter, Stephen M.
Publicado em 2013

A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease

Por Nygaard, Haakon B, Wagner, Allison F, Bowen, Garrett S, Good, Susan P, MacAvoy, Martha G, Strittmatter, Kurt A, Kaufman, Adam C, Rosenberg, Brian J, Sekine-Konno, Tomoko, Varma, Pradeep, Chen, Kewei, Koleske, Anthony J, Reiman, Eric M, Strittmatter, Stephen M, van Dyck, Christopher H
Publicado no Alzheimers Res Ther (2015)