Metabotropic Glutamate Receptor 5 is a Co-Receptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

Soluble Amyloid-β oligomers (Aβo) trigger Alzheimer’s disease (AD) pathophysiology and bind with high affinity to Cellular Prion Protein (PrP(C)). At the post-synaptic density (PSD), extracellular Aβo bound to lipid-anchored PrP(C) activates intracellular Fyn kinase to disrupt synapses. Here, we scr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Um, Ji Won, Kaufman, Adam C., Kostylev, Mikhail, Heiss, Jacqueline K., Stagi, Massimiliano, Takahashi, Hideyuki, Kerrisk, Meghan E., Vortmeyer, Alexander, Wisniewski, Thomas, Koleske, Anthony J., Gunther, Erik C., Nygaard, Haakon B., Strittmatter, Stephen M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3768018/
https://ncbi.nlm.nih.gov/pubmed/24012003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.06.036
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak