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Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease

Alzheimer’s disease-related phenotypes in mice can be rescued by blockade of either cellular prion protein or metabotropic glutamate receptor 5. We sought genetic and biochemical evidence that these proteins function cooperatively as an obligate complex in the brain. We show that cellular prion prot...

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Bibliografiske detaljer
Udgivet i:Brain
Main Authors: Haas, Laura T., Salazar, Santiago V., Kostylev, Mikhail A., Um, Ji Won, Kaufman, Adam C., Strittmatter, Stephen M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840505/
https://ncbi.nlm.nih.gov/pubmed/26667279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv356
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