Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network

Progranulin (PGRN) is implicated in Alzheimer’s disease (AD) as well as frontotemporal lobar degeneration. Genetic studies demonstrate an association of the common GRN rs5848 variant that results in reduced PGRN levels with increased risk for AD. However, the mechanisms by which PGRN reduction from...

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Bibliografske podrobnosti
izdano v:Acta Neuropathol
Main Authors: Takahashi, Hideyuki, Klein, Zoe A., Sarah, M. Bhagat, Kaufman, Adam C., Kostylev, Mikhail A., Ikezu, Tsuneya, Strittmatter, Stephen M.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391267/
https://ncbi.nlm.nih.gov/pubmed/28070672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1668-z
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