Reduction of Microglial Progranulin Does Not Exacerbate Pathology or Behavioral Deficits in Neuronal Progranulin-insufficient Mice

Loss-of-function mutations in progranulin (GRN), most of which cause progranulin haploinsufficiency, are a major autosomal dominant cause of frontotemporal dementia (FTD). Individuals with loss-of-function mutations on both GRN alleles develop neuronal ceroid lipofuscinosis (NCL), a lysosomal storag...

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發表在:Neurobiol Dis
Main Authors: Arrant, Andrew E., Filiano, Anthony J., Patel, Aashka R., Hoffmann, Madelyn Q., Boyle, Nicholas R., Kashyap, Shreya N., Onyilo, Vincent C., Young, Allen H., Roberson, Erik D.
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363848/
https://ncbi.nlm.nih.gov/pubmed/30448285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.11.011
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