Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test

Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia (FTD), a neurodegenerative disorder in which social behavior is disrupted. Progranulin-insufficient mice, both Grn(+/−) and Grn(−/−), are used as models of FTD due to GRN mutations, with G...

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Bibliografiska uppgifter
I publikationen:Genes Brain Behav
Huvudupphovsmän: Arrant, Andrew E., Filiano, Anthony J., Warmus, Brian A., Hall, Alicia M., Roberson, Erik D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943713/
https://ncbi.nlm.nih.gov/pubmed/27213486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/gbb.12300
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