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Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia
Loss-of-function mutations in progranulin (GRN), a secreted glycoprotein expressed by neurons and microglia, are a common autosomal dominant cause of frontotemporal dementia, a neurodegenerative disease commonly characterized by disrupted social and emotional behaviour. GRN mutations are thought to...
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| Publié dans: | Brain |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5965303/ https://ncbi.nlm.nih.gov/pubmed/28379303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awx060 |
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