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Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia

Loss-of-function mutations in progranulin (GRN), a secreted glycoprotein expressed by neurons and microglia, are a common autosomal dominant cause of frontotemporal dementia, a neurodegenerative disease commonly characterized by disrupted social and emotional behaviour. GRN mutations are thought to...

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Bibliografische gegevens
Gepubliceerd in:Brain
Hoofdauteurs: Arrant, Andrew E., Filiano, Anthony J., Unger, Daniel E., Young, Allen H., Roberson, Erik D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5965303/
https://ncbi.nlm.nih.gov/pubmed/28379303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awx060
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