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Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test
Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia (FTD), a neurodegenerative disorder in which social behavior is disrupted. Progranulin-insufficient mice, both Grn(+/−) and Grn(−/−), are used as models of FTD due to GRN mutations, with G...
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| Publicado en: | Genes Brain Behav |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5943713/ https://ncbi.nlm.nih.gov/pubmed/27213486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/gbb.12300 |
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