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Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network
Progranulin (PGRN) is implicated in Alzheimer’s disease (AD) as well as frontotemporal lobar degeneration. Genetic studies demonstrate an association of the common GRN rs5848 variant that results in reduced PGRN levels with increased risk for AD. However, the mechanisms by which PGRN reduction from...
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| Publicado no: | Acta Neuropathol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5391267/ https://ncbi.nlm.nih.gov/pubmed/28070672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1668-z |
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