Regulation of Tau Pathology by the Microglial Fractalkine Receptor

Aggregates of the hyperphosphorylated microtubule associated protein tau (MAPT) are an invariant neuropathological feature of tauopathies. Here we show that microglial neuroinflammation promotes MAPT phosphorylation and aggregation. First, lipopolysaccharide-induced microglial activation promotes hy...

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Detalhes bibliográficos
Main Authors: Bhaskar, Kiran, Konerth, Megan, Kokiko-Cochran, Olga N., Cardona, Astrid, Ransohoff, Richard M., Lamb, Bruce T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950825/
https://ncbi.nlm.nih.gov/pubmed/20920788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.08.023
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