Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

Pathological aggregation of tau is a hallmark of Alzheimer’s disease and related tauopathies. We have previously shown that the deficiency of the microglial fractalkine receptor (CX3CR1) led to the acceleration of tau pathology and memory impairment in an hTau mouse model of tauopathy. Here, we show...

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Publicat a:Brain
Autors principals: Maphis, Nicole, Xu, Guixiang, Kokiko-Cochran, Olga N., Jiang, Shanya, Cardona, Astrid, Ransohoff, Richard M., Lamb, Bruce T., Bhaskar, Kiran
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542622/
https://ncbi.nlm.nih.gov/pubmed/25833819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv081
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