Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

Pathological aggregation of tau is a hallmark of Alzheimer’s disease and related tauopathies. We have previously shown that the deficiency of the microglial fractalkine receptor (CX3CR1) led to the acceleration of tau pathology and memory impairment in an hTau mouse model of tauopathy. Here, we show...

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Enregistré dans:
Détails bibliographiques
Publié dans:Brain
Auteurs principaux: Maphis, Nicole, Xu, Guixiang, Kokiko-Cochran, Olga N., Jiang, Shanya, Cardona, Astrid, Ransohoff, Richard M., Lamb, Bruce T., Bhaskar, Kiran
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542622/
https://ncbi.nlm.nih.gov/pubmed/25833819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv081
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