Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

Pathological aggregation of tau is a hallmark of Alzheimer’s disease and related tauopathies. We have previously shown that the deficiency of the microglial fractalkine receptor (CX3CR1) led to the acceleration of tau pathology and memory impairment in an hTau mouse model of tauopathy. Here, we show...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Maphis, Nicole, Xu, Guixiang, Kokiko-Cochran, Olga N., Jiang, Shanya, Cardona, Astrid, Ransohoff, Richard M., Lamb, Bruce T., Bhaskar, Kiran
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542622/
https://ncbi.nlm.nih.gov/pubmed/25833819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv081
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