Loss of tau rescues inflammation-mediated neurodegeneration

Neuroinflammation is one of the neuropathological hallmarks of Alzheimer's disease (AD) and related tauopathies. Activated microglia spatially coexist with microtubule-associated protein tau (Mapt or tau)-burdened neurons in the brains of human AD and non-AD tauopathies. Numerous studies have s...

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Bibliographic Details
Published in:Front Neurosci
Main Authors: Maphis, Nicole, Xu, Guixiang, Kokiko-Cochran, Olga N., Cardona, Astrid E., Ransohoff, Richard M., Lamb, Bruce T., Bhaskar, Kiran
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Psychiatry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452825/
https://ncbi.nlm.nih.gov/pubmed/26089772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2015.00196
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