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Regulation of Tau Pathology by the Microglial Fractalkine Receptor
Aggregates of the hyperphosphorylated microtubule associated protein tau (MAPT) are an invariant neuropathological feature of tauopathies. Here we show that microglial neuroinflammation promotes MAPT phosphorylation and aggregation. First, lipopolysaccharide-induced microglial activation promotes hy...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2950825/ https://ncbi.nlm.nih.gov/pubmed/20920788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.08.023 |
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