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Regulation of Tau Pathology by the Microglial Fractalkine Receptor
Aggregates of the hyperphosphorylated microtubule associated protein tau (MAPT) are an invariant neuropathological feature of tauopathies. Here we show that microglial neuroinflammation promotes MAPT phosphorylation and aggregation. First, lipopolysaccharide-induced microglial activation promotes hy...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2950825/ https://ncbi.nlm.nih.gov/pubmed/20920788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.08.023 |
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