Regulation of Tau Pathology by the Microglial Fractalkine Receptor

Aggregates of the hyperphosphorylated microtubule associated protein tau (MAPT) are an invariant neuropathological feature of tauopathies. Here we show that microglial neuroinflammation promotes MAPT phosphorylation and aggregation. First, lipopolysaccharide-induced microglial activation promotes hy...

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Main Authors: Bhaskar, Kiran, Konerth, Megan, Kokiko-Cochran, Olga N., Cardona, Astrid, Ransohoff, Richard M., Lamb, Bruce T.
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950825/
https://ncbi.nlm.nih.gov/pubmed/20920788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.08.023
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