Delayed Amyloid Plaque Deposition and Behavioral Deficits in Outcrossed AβPP/PS1 Mice

Alzheimer’s disease (AD) is a progressive neurodegenerative dementia characterized by amyloid plaque accumulation, synapse/dendrite loss, and cognitive impairment. Transgenic mice expressing mutant forms of amyloid-β precursor protein (AβPP) and presenilin-1 (PS1) recapitulate several aspects of thi...

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Détails bibliographiques
Auteurs principaux: Couch, Brian A., Kerrisk, Meghan E., Kaufman, Adam C., Nygaard, Haakon B., Strittmatter, Stephen M., Koleske, Anthony J.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562562/
https://ncbi.nlm.nih.gov/pubmed/23047754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.23239
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