β-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or β-amyloid deposits

β-Amyloid (Aβ) polypeptide plays a critical role in the pathogenesis of Alzheimer's disease (AD), which is characterized by progressive decline of cognitive functions, formation of Aβ deposits and neurofibrillary tangles, and loss of neurons. Increased genetic production or direct intracerebral...

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Detalhes bibliográficos
Main Authors: Malm, Tarja, Ort, Michael, Tähtivaara, Leena, Jukarainen, Niko, Goldsteins, Gundars, Puoliväli, Jukka, Nurmi, Antti, Pussinen, Raimo, Ahtoniemi, Toni, Miettinen, Taina-Kaisa, Kanninen, Katja, Leskinen, Suvi, Vartiainen, Nina, Yrjänheikki, Juha, Laatikainen, Reino, Harris-White, Marni E., Koistinaho, Milla, Frautschy, Sally A., Bures, Jan, Koistinaho, Jari
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482667/
https://ncbi.nlm.nih.gov/pubmed/16723396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602896103
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