β-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or β-amyloid deposits

β-Amyloid (Aβ) polypeptide plays a critical role in the pathogenesis of Alzheimer's disease (AD), which is characterized by progressive decline of cognitive functions, formation of Aβ deposits and neurofibrillary tangles, and loss of neurons. Increased genetic production or direct intracerebral...

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Detalles Bibliográficos
Autores principales: Malm, Tarja, Ort, Michael, Tähtivaara, Leena, Jukarainen, Niko, Goldsteins, Gundars, Puoliväli, Jukka, Nurmi, Antti, Pussinen, Raimo, Ahtoniemi, Toni, Miettinen, Taina-Kaisa, Kanninen, Katja, Leskinen, Suvi, Vartiainen, Nina, Yrjänheikki, Juha, Laatikainen, Reino, Harris-White, Marni E., Koistinaho, Milla, Frautschy, Sally A., Bures, Jan, Koistinaho, Jari
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482667/
https://ncbi.nlm.nih.gov/pubmed/16723396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602896103
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