β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation

β-amyloid (Aβ), derived form the β-amyloid precursor protein (APP), is important for the pathogenesis of Alzheimer's disease (AD), which is characterized by progressive decline of cognitive functions, formation of Aβ plaques and neurofibrillary tangles, and loss of neurons. However, introducing...

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Detalhes bibliográficos
Main Authors: Koistinaho, Milla, Kettunen, Mikko I., Goldsteins, Gundars, Keinänen, Riitta, Salminen, Antero, Ort, Michael, Bures, Jan, Liu, David, Kauppinen, Risto A., Higgins, Linda S., Koistinaho, Jari
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122238/
https://ncbi.nlm.nih.gov/pubmed/11818564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032670899
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