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Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction is recognized as one of the key elements contributing to the pathology. Mitochondria are the major source of intracellular reactive oxygen species (ROS). Increased production of ROS as well as oxidative damage of proteins and lipids h...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vehviläinen, Piia, Koistinaho, Jari, Gundars, Goldsteins
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023018/
https://ncbi.nlm.nih.gov/pubmed/24847211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00126
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