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Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction is recognized as one of the key elements contributing to the pathology. Mitochondria are the major source of intracellular reactive oxygen species (ROS). Increased production of ROS as well as oxidative damage of proteins and lipids h...

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書目詳細資料
Main Authors: Vehviläinen, Piia, Koistinaho, Jari, Gundars, Goldsteins
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023018/
https://ncbi.nlm.nih.gov/pubmed/24847211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00126
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