ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

BACKGROUND: A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteoglycanases are specialized in the degradation of chondroitin sulfate proteoglycans and participate in mechanisms mediating neuroplasticity. Despite the beneficial effect of ADAMTS-4 on neurorepair after spinal...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Lemarchant, Sighild, Pomeshchik, Yuriy, Kidin, Iurii, Kärkkäinen, Virve, Valonen, Piia, Lehtonen, Sarka, Goldsteins, Gundars, Malm, Tarja, Kanninen, Katja, Koistinaho, Jari
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727317/
https://ncbi.nlm.nih.gov/pubmed/26809777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0078-3
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