The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motoneurons and degradation of the neuromuscular junctions (NMJ). Consistent with the dying-back hypothesis of motoneuron degeneration the decline in synaptic function initiates from the presynaptic terminals in ALS. Oxi...

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Autores principales: Pollari, Eveliina, Goldsteins, Gundars, Bart, Geneviève, Koistinaho, Jari, Giniatullin, Rashid
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026683/
https://ncbi.nlm.nih.gov/pubmed/24860432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00131
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