The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motoneurons and degradation of the neuromuscular junctions (NMJ). Consistent with the dying-back hypothesis of motoneuron degeneration the decline in synaptic function initiates from the presynaptic terminals in ALS. Oxi...

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Bibliographic Details
Main Authors: Pollari, Eveliina, Goldsteins, Gundars, Bart, Geneviève, Koistinaho, Jari, Giniatullin, Rashid
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026683/
https://ncbi.nlm.nih.gov/pubmed/24860432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00131
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