β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation

β-amyloid (Aβ), derived form the β-amyloid precursor protein (APP), is important for the pathogenesis of Alzheimer's disease (AD), which is characterized by progressive decline of cognitive functions, formation of Aβ plaques and neurofibrillary tangles, and loss of neurons. However, introducing...

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מידע ביבליוגרפי
Main Authors: Koistinaho, Milla, Kettunen, Mikko I., Goldsteins, Gundars, Keinänen, Riitta, Salminen, Antero, Ort, Michael, Bures, Jan, Liu, David, Kauppinen, Risto A., Higgins, Linda S., Koistinaho, Jari
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences 2002
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC122238/
https://ncbi.nlm.nih.gov/pubmed/11818564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032670899
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