A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

The only treatment of patients with acute ischemic stroke is thrombolytic therapy, which benefits only a fraction of stroke patients. Both human and experimental studies indicate that ischemic stroke involves secondary inflammation that significantly contributes to the outcome after ischemic insult....

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Hauptverfasser: Yrjänheikki, Juha, Tikka, Tiina, Keinänen, Riitta, Goldsteins, Gundars, Chan, Pak H., Koistinaho, Jari
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1999
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC23976/
https://ncbi.nlm.nih.gov/pubmed/10557349
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