Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia

Minocycline, a semisynthetic tetracycline derivative, protects brain against global and focal ischemia in rodents. We examined whether minocycline reduces excitotoxicity in primary neuronal cultures. Minocycline (0.02 μm) significantly increased neuronal survival in mixed spinal cord (SC) cultures t...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Tikka, Tiina, Fiebich, Bernd L., Goldsteins, Gundars, Keinänen, Riitta, Koistinaho, Jari
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762519/
https://ncbi.nlm.nih.gov/pubmed/11306611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-08-02580.2001
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