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Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

Ischemic stroke is the most common life-threatening neurological disease and has limited therapeutic options. One component of ischemic neuronal death is inflammation. Here we show that doxycycline and minocycline, which are broad-spectrum antibiotics and have antiinflammatory effects independent of...

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Autores principales: Yrjänheikki, Juha, Keinänen, Riitta, Pellikka, Milla, Hökfelt, Tomas, Koistinaho, Jari
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC28119/
https://ncbi.nlm.nih.gov/pubmed/9861045
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