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Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques
Memory impairment progressing to dementia is the main clinical symptom of Alzheimer's disease (AD). AD is characterized histologically by the presence of β-amyloid (Aβ) plaques and neurofibrillary tangles in specific brain regions. Although Aβ derived from the Aβ precursor protein (β-APP) is be...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC64740/ https://ncbi.nlm.nih.gov/pubmed/11724968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261562998 |
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