Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques

Memory impairment progressing to dementia is the main clinical symptom of Alzheimer's disease (AD). AD is characterized histologically by the presence of β-amyloid (Aβ) plaques and neurofibrillary tangles in specific brain regions. Although Aβ derived from the Aβ precursor protein (β-APP) is be...

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Bibliographic Details
Main Authors: Koistinaho, Milla, Ort, Michael, Cimadevilla, Jose M., Vondrous, Roman, Cordell, Barbara, Koistinaho, Jari, Bures, Jan, Higgins, Linda S.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC64740/
https://ncbi.nlm.nih.gov/pubmed/11724968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261562998
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