Augmented Senile Plaque Load in Aged Female β-Amyloid Precursor Protein-Transgenic Mice

Transgenic mice (Tg2576) overexpressing human β-amyloid precursor protein with the Swedish mutation (APP695SWE) develop Alzheimer’s disease-like amyloid β protein (Aβ) deposits by 8 to 10 months of age. These mice show elevated levels of Aβ40 and Aβ42, as well as an age-related increase in diffuse a...

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Detalhes bibliográficos
Main Authors: Callahan, Michael J., Lipinski, William J., Bian, Feng, Durham, Robert A., Pack, Amy, Walker, Lary C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2001
Assuntos:
Animal Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850367/
https://ncbi.nlm.nih.gov/pubmed/11238065
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