Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice

OBJECTIVE: We studied the mechanistic links between fibrocalcific changes in the aortic valve and aortic valve function in mice homozygous for a hypomorphic epidermal growth factor receptor mutation (Wave mice). We also studied myocardial responses to aortic valve dysfunction in Wave mice. APPROACH...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Hajj, Georges P., Chu, Yi, Lund, Donald D., Magida, Jason A., Funk, Nathan D., Brooks, Robert M., Baumbach, Gary L., Zimmerman, Kathy A., Davis, Melissa K., El Accaoui, Ramzi N., Hameed, Tariq, Doshi, Hardik, Chen, BiYi, Leinwand, Leslie A., Song, Long-Sheng, Heistad, Donald D., Weiss, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482792/
https://ncbi.nlm.nih.gov/pubmed/25997932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.305729
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