Osteoprotegerin Inhibits Aortic Valve Calcification and Preserves Valve Function in Hypercholesterolemic Mice

BACKGROUND: There are no rigorously confirmed effective medical therapies for calcific aortic stenosis. Hypercholesterolemic Ldlr (−/−) Apob (100/100) mice develop calcific aortic stenosis and valvular cardiomyopathy in old age. Osteoprotegerin (OPG) modulates calcification in bone and blood vessels...

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Main Authors: Weiss, Robert M., Lund, Donald D., Chu, Yi, Brooks, Robert M., Zimmerman, Kathy A., Accaoui, Ramzi El, Davis, Melissa K., Hajj, Georges P., Zimmerman, M. Bridget, Heistad, Donald D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675204/
https://ncbi.nlm.nih.gov/pubmed/23762316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065201
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