Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice

OBJECTIVE: We studied the mechanistic links between fibrocalcific changes in the aortic valve and aortic valve function in mice homozygous for a hypomorphic epidermal growth factor receptor mutation (Wave mice). We also studied myocardial responses to aortic valve dysfunction in Wave mice. APPROACH...

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Hajj, Georges P., Chu, Yi, Lund, Donald D., Magida, Jason A., Funk, Nathan D., Brooks, Robert M., Baumbach, Gary L., Zimmerman, Kathy A., Davis, Melissa K., El Accaoui, Ramzi N., Hameed, Tariq, Doshi, Hardik, Chen, BiYi, Leinwand, Leslie A., Song, Long-Sheng, Heistad, Donald D., Weiss, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482792/
https://ncbi.nlm.nih.gov/pubmed/25997932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.305729
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