Discovery of an Experimental Model of Unicuspid Aortic Valve

BACKGROUND: The epithelial growth factor receptor family of tyrosine kinases modulates embryonic formation of semilunar valves. We hypothesized that mice heterozygous for a dominant loss‐of‐function mutation in epithelial growth factor receptor, which are Egfr (Vel/+) mice, would develop anomalous a...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Weiss, Robert M., Chu, Yi, Brooks, Robert M., Lund, Donald D., Cheng, Justine, Zimmerman, Kathy A., Kafa, Melissa K., Sistla, Phanicharan, Doshi, Hardik, Shao, Jian Q., El Accaoui, Ramzi N., Otto, Catherine M., Heistad, Donald D.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064885/
https://ncbi.nlm.nih.gov/pubmed/29960994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.006908
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