Discovery of an Experimental Model of Unicuspid Aortic Valve

BACKGROUND: The epithelial growth factor receptor family of tyrosine kinases modulates embryonic formation of semilunar valves. We hypothesized that mice heterozygous for a dominant loss‐of‐function mutation in epithelial growth factor receptor, which are Egfr (Vel/+) mice, would develop anomalous a...

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Dettagli Bibliografici
Pubblicato in:J Am Heart Assoc
Autori principali: Weiss, Robert M., Chu, Yi, Brooks, Robert M., Lund, Donald D., Cheng, Justine, Zimmerman, Kathy A., Kafa, Melissa K., Sistla, Phanicharan, Doshi, Hardik, Shao, Jian Q., El Accaoui, Ramzi N., Otto, Catherine M., Heistad, Donald D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064885/
https://ncbi.nlm.nih.gov/pubmed/29960994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.006908
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