Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under five years of age. We sought to engineer a viral antigen that provides greater protection than currently available vaccines and focused on antigenic site Ø, a metastable site specific to the prefusion state...

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Vydáno v:Science
Hlavní autoři: McLellan, Jason S., Chen, Man, Joyce, M. Gordon, Sastry, Mallika, Stewart-Jones, Guillaume B. E., Yang, Yongping, Zhang, Baoshan, Chen, Lei, Srivatsan, Sanjay, Zheng, Anqi, Zhou, Tongqing, Graepel, Kevin W., Kumar, Azad, Moin, Syed, Boyington, Jeffrey C., Chuang, Gwo-Yu, Soto, Cinque, Baxa, Ulrich, Bakker, Arjen Q., Spits, Hergen, Beaumont, Tim, Zheng, Zizheng, Xia, Ningshao, Ko, Sung-Youl, Todd, John-Paul, Rao, Srinivas, Graham, Barney S., Kwong, Peter D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461862/
https://ncbi.nlm.nih.gov/pubmed/24179220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1243283
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