Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein

Prevention efforts for respiratory syncytial virus (RSV) have been advanced due to the recent isolation and characterization of antibodies that specifically recognize the prefusion conformation of the RSV fusion (F) glycoprotein. These potently neutralizing antibodies are in clinical development for...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Gilman, Morgan S. A., Moin, Syed M., Mas, Vicente, Chen, Man, Patel, Nita K., Kramer, Kari, Zhu, Qing, Kabeche, Stephanie C., Kumar, Azad, Palomo, Concepción, Beaumont, Tim, Baxa, Ulrich, Ulbrandt, Nancy D., Melero, José A., Graham, Barney S., McLellan, Jason S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498696/
https://ncbi.nlm.nih.gov/pubmed/26161532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005035
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