Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera

Respiratory syncytial virus (RSV) is estimated to claim more lives among infants <1 year old than any other single pathogen, except malaria, and poses a substantial global health burden. Viral entry is mediated by a type I fusion glycoprotein (F) that transitions from a metastable prefusion (pre-...

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Pubblicato in:Sci Transl Med
Autori principali: Ngwuta, Joan O., Chen, Man, Modjarrad, Kayvon, Joyce, M. Gordon, Kanekiyo, Masaru, Kumar, Azad, Yassine, Hadi M., Moin, Syed M., Killikelly, April M., Chuang, Gwo-Yu, Druz, Aliaksandr, Georgiev, Ivelin S., Rundlet, Emily J., Sastry, Mallika, Stewart-Jones, Guillaume B. E., Yang, Yongping, Zhang, Baoshan, Nason, Martha C., Capella, Cristina, Peeples, Mark E., Ledgerwood, Julie E., McLellan, Jason S., Kwong, Peter D., Graham, Barney S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672383/
https://ncbi.nlm.nih.gov/pubmed/26468324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac4241
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