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Precision cancer mouse models through genome editing with CRISPR-Cas9
The cancer genome is highly complex, with hundreds of point mutations, translocations, and chromosome gains and losses per tumor. To understand the effects of these alterations, precise models are needed. Traditional approaches to the construction of mouse models are time-consuming and laborious, re...
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| Veröffentlicht in: | Genome Med |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4460969/ https://ncbi.nlm.nih.gov/pubmed/26060510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0178-7 |
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