Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

CRISPR/Cas9 derived from the bacterial adaptive immunity pathway is a powerful tool for genome editing, but the safety profiles of in vivo delivered Cas9 (including host immune responses to the bacterial Cas9 protein) have not been comprehensively investigated in model organisms. Nonalcoholic steato...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Gene Ther
Prif Awduron: Wang, Dan, Mou, Haiwei, Li, Shaoyong, Li, Yingxiang, Hough, Soren, Tran, Karen, Li, Jia, Yin, Hao, Anderson, Daniel G., Sontheimer, Erik J., Weng, Zhiping, Gao, Guangping, Xue, Wen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc. 2015
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509492/
https://ncbi.nlm.nih.gov/pubmed/26086867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2015.087
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