Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

CRISPR/Cas9 derived from the bacterial adaptive immunity pathway is a powerful tool for genome editing, but the safety profiles of in vivo delivered Cas9 (including host immune responses to the bacterial Cas9 protein) have not been comprehensively investigated in model organisms. Nonalcoholic steato...

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Detaylı Bibliyografya
Yayımlandı:Hum Gene Ther
Asıl Yazarlar: Wang, Dan, Mou, Haiwei, Li, Shaoyong, Li, Yingxiang, Hough, Soren, Tran, Karen, Li, Jia, Yin, Hao, Anderson, Daniel G., Sontheimer, Erik J., Weng, Zhiping, Gao, Guangping, Xue, Wen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc. 2015
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509492/
https://ncbi.nlm.nih.gov/pubmed/26086867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2015.087
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