CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion

CRISPR is widely used to disrupt gene function by inducing small insertions and deletions. Here, we show that some single-guide RNAs (sgRNAs) can induce exon skipping or large genomic deletions that delete exons. For example, CRISPR-mediated editing of β-catenin exon 3, which encodes an autoinhibito...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Genome Biol
Autors principals: Mou, Haiwei, Smith, Jordan L., Peng, Lingtao, Yin, Hao, Moore, Jill, Zhang, Xiao-Ou, Song, Chun-Qing, Sheel, Ankur, Wu, Qiongqiong, Ozata, Deniz M., Li, Yingxiang, Anderson, Daniel G., Emerson, Charles P., Sontheimer, Erik J., Moore, Melissa J., Weng, Zhiping, Xue, Wen
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470253/
https://ncbi.nlm.nih.gov/pubmed/28615073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1237-8
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars