CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion

CRISPR is widely used to disrupt gene function by inducing small insertions and deletions. Here, we show that some single-guide RNAs (sgRNAs) can induce exon skipping or large genomic deletions that delete exons. For example, CRISPR-mediated editing of β-catenin exon 3, which encodes an autoinhibito...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Mou, Haiwei, Smith, Jordan L., Peng, Lingtao, Yin, Hao, Moore, Jill, Zhang, Xiao-Ou, Song, Chun-Qing, Sheel, Ankur, Wu, Qiongqiong, Ozata, Deniz M., Li, Yingxiang, Anderson, Daniel G., Emerson, Charles P., Sontheimer, Erik J., Moore, Melissa J., Weng, Zhiping, Xue, Wen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470253/
https://ncbi.nlm.nih.gov/pubmed/28615073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1237-8
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