CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling

CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is well-established, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gene knock-in. Here we developed CRISPR-based Somatic Oncogene...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Genome Med
Autori principali: Mou, Haiwei, Ozata, Deniz M., Smith, Jordan L., Sheel, Ankur, Kwan, Suet-Yan, Hough, Soren, Kucukural, Alper, Kennedy, Zachary, Cao, Yueying, Xue, Wen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466773/
https://ncbi.nlm.nih.gov/pubmed/30987660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0627-9
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