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Genomic amplifications cause false positives in CRISPR screens
In CRISPR-based screens for essential genes, Aguirre et al. and Munoz et al. show that gene-independent targeting of genomic amplifications in human cancer cell lines reduces proliferation or survival. The correlation between CRISPR target site copy number and lethality demonstrates the need for scr...
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| Publicat a: | Cancer Discov |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4975541/ https://ncbi.nlm.nih.gov/pubmed/27485003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0665 |
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