Correction of copy number induced false positives in CRISPR screens

Cell autonomous cancer dependencies are now routinely identified using CRISPR loss-of-function viability screens. However, a bias exists that makes it difficult to assess the true essentiality of genes located in amplicons, since the entire amplified region can exhibit lethal scores. These false-pos...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: de Weck, Antoine, Golji, Javad, Jones, Michael D., Korn, Joshua M., Billy, Eric, McDonald, E. Robert, Schmelzle, Tobias, Bitter, Hans, Kauffmann, Audrey
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067744/
https://ncbi.nlm.nih.gov/pubmed/30024886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006279
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