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Genomic amplifications cause false positives in CRISPR screens
In CRISPR-based screens for essential genes, Aguirre et al. and Munoz et al. show that gene-independent targeting of genomic amplifications in human cancer cell lines reduces proliferation or survival. The correlation between CRISPR target site copy number and lethality demonstrates the need for scr...
में बचाया:
| में प्रकाशित: | Cancer Discov |
|---|---|
| मुख्य लेखकों: | , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4975541/ https://ncbi.nlm.nih.gov/pubmed/27485003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0665 |
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