Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis

Genetic lesions that activate KRAS account for ∼30% of the 1.6 million annual cases of lung cancer. Despite clinical need, KRAS is still undruggable using traditional small-molecule drugs/inhibitors. When oncogenic Kras is suppressed by RNA interference, tumors initially regress but eventually recur...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mou, Haiwei, Moore, Jill, Malonia, Sunil K., Li, Yingxiang, Ozata, Deniz M., Hough, Soren, Song, Chun-Qing, Smith, Jordan L., Fischer, Andrew, Weng, Zhiping, Green, Michael R., Xue, Wen
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389295/
https://ncbi.nlm.nih.gov/pubmed/28320962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620861114
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