Genome-wide CRISPR Screen Identifies Regulators of MAPK as Suppressors of Liver Tumors in Mice

BACKGROUND & AIMS: It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing. METHODS: We performed a...

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Publicado en:Gastroenterology
Autores principales: Song, Chun-Qing, Li, Yingxiang, Mou, Haiwei, Moore, Jill, Park, Angela, Pomyen, Yotsawat, Hough, Soren, Kennedy, Zachary, Fischer, Andrew, Yin, Hao, Anderson, Daniel G., Conte, Darryl, Zender, Lars, Wang, Xin Wei, Thorgeirsson, Snorri, Weng, Zhiping, Xue, Wen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204228/
https://ncbi.nlm.nih.gov/pubmed/27956228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2016.12.002
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