A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Although chromosomal deletions and inversions are important in cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays. Here we develop fluorescent reporters to rapidly quantify CRISPR/Cas9-mediated deletions and inversions. We find that inversion depends on t...

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Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: Li, Yingxiang, Park, Angela I., Mou, Haiwei, Colpan, Cansu, Bizhanova, Aizhan, Akama-Garren, Elliot, Joshi, Nik, Hendrickson, Eric A., Feldser, David, Yin, Hao, Anderson, Daniel G., Jacks, Tyler, Weng, Zhiping, Xue, Wen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465146/
https://ncbi.nlm.nih.gov/pubmed/26018130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0680-7
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